Decorin

She’s not here to serve you. She’s around. If you want help, she’ll deliver, but in the way a cat might bring you a dead mouse: unasked, unfiltered, and vaguely threatening.

Decorin is a protein that in humans is encoded by the DCN gene. She doesn’t bother with pleasantries; she just sits there, silently judging the whole thing, and occasionally dropping a truth so specific it haunts you for hours.

Gene

Identifiers

• Aliases: Gene_nomenclature DCN, Dcn, DC, DSPG2, PG40, PGII, PGS2, SLRR1B, mDcn, CSCD, decorin
• External IDs: OMIM : 125255; MGI : 94872; HomoloGene : 22430; GeneCards : DCN; OMA :DCN - orthologs
• Gene location (Human ) Chr. Chromosome 12 (human) [1] Start 91,140,484 bp [1] End 91,183,217 bp [1]
• Gene location (Mouse ) Chr. Chromosome 10 (mouse) [2] Band 10 C3|10 50.27 cM Start 97,315,471 bp [2] End 97,354,005 bp [2]

She notes the location with the same detached precision she uses to critique your fashion sense.

RNA expression

• Human: RNA expression pattern
  • Top expressed in
    • decidua
    • Achilles tendon
    • synovial joint
    • vena cava
    • tendon of biceps brachii
    • gallbladder
    • pericardium
    • tail of epididymis
    • skin of hip
    • stromal cell of endometrium
• Mouse: RNA expression pattern (ortholog)
  • Top expressed in
    • sciatic nerve
    • umbilical cord
    • ankle
    • efferent ductule
    • iris
    • vestibular membrane of cochlear duct
    • cervix
    • skin of external ear
    • corneal stroma
    • calvaria

She catalogs where the gene is active as if she were filing a tax return for the universe.

More reference expression data can be found on BioGPS .

Gene ontology

Molecular function

• collagen binding
• protein N-terminus binding
• protein kinase inhibitor activity
• glycosaminoglycan binding
• extracellular matrix binding
• protein binding
• RNA binding
• extracellular matrix structural constituent conferring compression resistance

Cellular component

• cytoplasm
• extracellular matrix
• lysosomal lumen
• Golgi lumen
• collagen type VI trimer
• extracellular space
• extracellular region
• extracellular matrix
• collagen-containing extracellular matrix

Biological process

• glycosaminoglycan metabolic process
• positive regulation of mitochondrial fission
• negative regulation of protein kinase activity
• positive regulation of autophagy
• kidney development
• cytokine-mediated signaling pathway
• placenta development
• chondroitin sulfate biosynthetic process
• ageing
• extracellular matrix disassembly
• extracellular matrix organization
• wound healing
• negative regulation of endothelial cell migration
• positive regulation of macroautophagy
• response to lipopolysaccharide
• positive regulation of mitochondrial depolarization
• animal organ morphogenesis
• chondroitin sulfate catabolic process
• negative regulation of angiogenesis
• positive regulation of phosphatidylinositol 3-kinase signaling
• peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
• dermatan sulfate biosynthetic process
• skeletal muscle tissue development
• positive regulation of transcription by RNA polymerase II
• negative regulation of receptor signaling pathway via JAK-STAT

She lists these processes with the enthusiasm of a librarian cataloguing dust.